Effects of Hydroxytyrosol Administration in Anthropometric Parameters in Overweight and Obese Women
Launched by NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS · Mar 19, 2020
Trial Information
Current as of June 07, 2025
Completed
Keywords
ClinConnect Summary
Hydroxytyrosol is an extra virgin olive oil phenolic compound which has known protective effects in LDL oxidation and reduces oxidative stress. Olive oil has been associated with enhanced weight loss, and hydroxytyrosol could have a potential role in this.
Participants entered the study after signing the informed consent document. Detailed medical and family history was taken at baseline visit, and measurement of height, body weight, body fat and visceral fat were also made. Each participant visited a dietitian the same day and written consultation concerning the diet to be followed was gi...
Gender
FEMALE
Eligibility criteria
- Inclusion Criteria:
- • Overweight and obese women. Stable body weight (\<5% variation) during the past 3 months before enrollment. Stable hypolipidemic treatment for at least 3 months before enrollment.
- Exclusion Criteria:
- • Diabetes mellitus
- • Neoplasms
- • Autoimmune conditions
- • Psychiatric disorders (excluding stable depressive disorder)
- • Hyper/hypo-thyroidism with recent changes in medical treatment during the past 6 months before enrollment
- • Renal impairment, defined as estimated Glomerular Filtration Rate (MDRD) \<60millilitres/min
- • Heart failure, defined as left ventricle Ejection Fraction \<40%, use of diuretics or other treatment due to heart failure (antihypertensive medications allowed)
- • Impaired liver function, defined as liver transaminases values twice above the upper normal range
- • Malabsorption status (inflammatory bowel disease, previous bariatric surgery, chronic pancreatitis)
- • Medical treatment known to influence body weight (steroids, oestrogens/ progesterone, topiramate, mirtazapine or anti-obesity treatment)
- • Unwillingness to participate to the study
- • Baseline waist circumference \>130cm due to technical difficulties in visceral fat measurement
- • Pregnancy, lactation
About National And Kapodistrian University Of Athens
The National and Kapodistrian University of Athens is a prestigious academic institution in Greece, renowned for its commitment to advancing medical research and education. With a strong emphasis on interdisciplinary collaboration, the university fosters innovative clinical trials aimed at improving healthcare outcomes. Its dedicated research teams leverage cutting-edge methodologies and a diverse range of expertise to address critical health challenges. As a clinical trial sponsor, the university prioritizes ethical standards and the welfare of participants, contributing significantly to the global body of medical knowledge and the development of new therapeutic interventions.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Athens, , Greece
Patients applied
Trial Officials
Nikolaos Tentolouris, MD,PhD
Principal Investigator
National Kapodistrian University of Athens
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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