Effectiveness of Hyaluronic Acid in the Regeneration of Infrabony Defects

Launched by UNIVERSITY OF ROMA LA SAPIENZA · Mar 23, 2020

Keywords

ClinConnect Summary

Intrabony defects associated with periodontal pockets represent a risk factor for periodontitis progression and additional loss of attachment if left untreated.

Over the years, several strategies have been implemented for their surgically reconstruction with the aim of pocket reduction and clinical attachment level gain.

Grafting of intrabony periodontal defects has been used extensively over the years incorporating various materials, including autogenic bone, demineralized allogenic bone, xenogenic and alloplastic materials. Controlled clinical studies have shown a significantly higher g...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• Patient related:
• • adults aged 18-65 years with periodontal disease
• • sites with infrabony defects and persisting pockets \[probing pocket depth (PPD) ≥ 5 mm and bleeding on probing (BOP)\] at re-evaluation 6 weeks after non-surgical periodontal therapy
• • full-mouth plaque score (FMPS)1 and full-mouth bleeding score (FMBS)2 \< 20% before surgery
• • at least one radiographically detectable infrabony lesion,3
• • good physical health.
• Site-specific:
• • Interproximal angular defects on single-rooted teeth
• • radiographic infrabony component ≥ 3 mm
• • PPD ≥ 6 mm and CAL ≥ 7 mm.
• Exclusion Criteria:
• • relevant medical conditions contraindicating surgical interventions
• • pregnancy or lactation
• • tobacco smoking
• • untreated periodontal conditions
• • any condition associated with poor compliance or failure to maintain good oral hygiene
• • acute infectious lesions in areas intended for surgery
• • teeth with grade 2 or higher mobility
• • restorations or carious lesions on root surfaces that are associated with the intrabony defect.