Study of Circulating Monocytes in Patients With Ischemic Vascular Disease

Launched by UCONN HEALTH · Mar 23, 2020

Keywords

ClinConnect Summary

This clinical trial is investigating the role of specific white blood cells called monocytes in patients who have experienced a heart attack or an ischemic stroke, which is a type of stroke caused by a blockage in a blood vessel to the brain. Researchers want to understand how these monocytes respond to injuries in the heart and brain, and how they might help the body heal by producing certain proteins and substances. By studying these cells, the researchers hope to gain insights that could improve treatments for heart and brain injuries in the future.

To participate in the study, individuals must be at least 18 years old and fall into one of several groups: those who have had a STEMI or NSTEMI heart attack, people with stable coronary artery disease, individuals who have suffered an ischemic stroke, or healthy volunteers without chronic health issues. Participants can expect to undergo tests and provide samples that will help researchers learn more about how the body responds to these serious health conditions. The study is currently recruiting, so if you or someone you know fits the criteria, this could be a valuable opportunity to contribute to important medical research.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • STEMI Patients: Men and women aged 18 years and over, with symptoms, physical signs and ECG changes characteristic of STEMI.
• • NSTEMI Patients: Men and women aged 18 years and over, with symptoms, physical signs and ECG changes characteristic of NSTEMI.
• • Stable CAD Patients: men and women aged 18 years and older with coronary artery disease proven by prior MI history, angiography or stress test but without any unstable angina or acute coronary syndrome.
• • Ischemic Stroke Patients: Men and women aged 18 years and over, with symptoms, physical signs and CT/MRI changes characteristic of ischemic stroke.
• • Healthy Controls: Men and women aged 18 years and over, without heart failure, coronary disease, hypertension, diabetes or other chronic diseases. Control subjects will be recruited from within the community of UConn Health via advertisement.
• Exclusion Criteria:
• • Subjects who are unable to give informed consent (with the exception of the ischemic stroke arm patients, see Protocol Design below) and pregnant subjects.
• • Subjects who had any history of embolic, ischemic or hemorrhagic stroke within the last 12 months.