Brown Adipose Tissue Activation by Spinal Cord Stimulation

Launched by OREGON HEALTH AND SCIENCE UNIVERSITY · Mar 26, 2020

Keywords

ClinConnect Summary

This clinical trial is examining whether spinal cord stimulation (SCS), a treatment typically used for managing pain, can also help people lose weight and improve conditions like Type 2 diabetes. The study is looking at how SCS might boost the metabolism of brown fat, which could lead to weight loss and better blood sugar control. They are currently recruiting participants aged 21 to 70 who have ongoing nerve-related pain in their legs or back and are planning to receive SCS for pain relief. Additionally, participants should have a body mass index (BMI) between 25 and 45, which generally indicates being overweight or moderately obese.

If you qualify and decide to participate, you can expect to receive SCS as part of your pain management plan, while also contributing to important research that may help others in the future. It's important to note that certain people won't be eligible, such as those who smoke regularly, are pregnant, or have recently lost or gained a significant amount of weight. This trial aims to explore new ways to support weight loss and manage diabetes, potentially benefiting many individuals dealing with these health challenges.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age: 21-70 years
• • 2. Persistent neuropathic leg and back pain
• • 3. Subjects who are already planning to undergo SCS for pain
• • 4. Subjects who have not received a prior SCS trial for pain
• • 5. Subjects with a BMI of 25-45, using formula; weight (lb) / \[height (in)\]2 x 703
• Exclusion Criteria:
• • 1. Not considering SCS for pain
• • 2. Forensic patient
• • 3. Taking beta blockers
• • 4. Weight change \> 5% within last 3 months
• • 5. Habitual tobacco use
• • 6. Habitual excessive alcohol use
• • 7. Pregnancy
• • 8. Decisionally impaired adults
• • 9. Children
• • 10. Neonates
• • 11. Subjects with a BMI of \<25 or \>45