Comparison of Imaging Quality Between Spectral Photon Counting Computed Tomography (SPCCT) and Dual Energy Computed Tomography (DECT)

Launched by HOSPICES CIVILS DE LYON · Mar 30, 2020

Keywords

ClinConnect Summary

This clinical trial is studying a new type of imaging called Spectral Photon Counting Computed Tomography (SPCCT) to see if it produces better quality images compared to the standard Dual Energy Computed Tomography (DECT). The goal is to find out if SPCCT can help doctors get clearer pictures of various body parts, which could lead to more accurate diagnoses for conditions like diabetic foot ulcers, kidney stones, and heart disease, among others. The study will involve taking images with and without a contrast agent, which is a special dye used to improve visibility in scans.

To participate in this trial, individuals should be between the ages of 65 and 74 and have certain medical conditions, such as diabetes or coronary artery disease. It's important that participants are not allergic to the contrast dye and meet other specific health criteria. Those who join the study can expect to undergo imaging tests that might help improve the way doctors understand their health issues. If you or a loved one are interested, it's a great opportunity to contribute to research that could enhance medical imaging in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• * Patients presenting following one of following medical conditions:
• • 1. Asymptomatic type 1 or 2 diabetes as regard to cardiovascular risks
• • 2. Diabetic foot ulcer
• • 3. Adrenal glands lesions: Adrenal incidentaloma or hyperaldosteronism or macroadenoma
• • 4. Urinary stone(s)
• • 5. Known Coronary artery disease: Stent imaging or control of calcified plaques
• • 6. Diffuse Interstitial Lung Diseases: Idiopathic Pulmonary Fibrosis, Hypersensitivity Pneumonitis, Ground Glass Opacification, Chronic Thromboembolic Pulmonary Hypertension
• • 7. Conductive hearing loss
• • 8. Brain stroke (late or post thrombectomy)
• • 9. Intracranial arteriovenous malformation treated with coils or Onyx
• • 10. Joints diseases in haemophilia
• • 11. Ear/temporal bone
• • 12. Colorectal carcinosis
• • 13. Dissection aortique de type A opérée ou de type B non opérée, hématome intramural
• • Patient has accepted to participate to the study and has signed the written consent;
• • Pre-menopausal women only: Negative urinary pregnancy test on the day of imaging before the administration of study drug;
• • Patient is affiliated to the French social security
• Exclusion Criteria:
• • Contraindication to the use of iodine containing contrast media (including subjects with suspicion for/or known to have NSF) (if injection);
• • History of severe allergic or anaphylactic reaction to any allergen including drugs and contrast agents (as judged by the investigator, taking into account the intensity of the event);
• • History of delayed major or delayed cutaneous reaction to Iomeron injection
• • Estimated Glomerular Filtration Rate (eGFR) value \< 30 mL/min/1.73 m2 derived from a serum creatinine result within 1 month before the imaging for examinations with contrast agent.
• • Any subject on hemodialysis or peritoneal dialysis;
• • Suspected clinical instability or unpredictability of the clinical course during the study period (e.g. due to previous surgery);
• • Pregnant or nursing (including pumping for storage and feeding);
• • Patient under guardianship, curatorship or safeguard of justice.