The Influence of Mitochondrial-Derived Reactive Oxygen Species on Racial Disparities in Neurovascular Function

Launched by AUBURN UNIVERSITY · Apr 2, 2020

Keywords

ClinConnect Summary

This clinical trial is investigating why Black individuals may have a higher risk of heart and blood vessel problems compared to white individuals. The researchers want to understand if certain substances produced by cells, called mitochondrial reactive oxygen species, affect how blood vessels work and how the nervous system controls blood pressure in different racial groups. The study aims to uncover potential reasons for these differences in health, especially concerning blood pressure and heart disease risk. Additionally, it will explore if these substances can help improve blood pressure and blood vessel function in people with slightly elevated blood pressure.

To participate in this study, individuals should be between the ages of 19 and 75, have a blood pressure no higher than 150/90 mmHg, and a healthy weight (BMI below 35). Participants should also be free from certain health conditions, including diabetes, kidney disease, and cardiovascular issues, and should not be smokers. Those who join the study can expect to undergo tests and procedures to help researchers gather valuable information. It's important to note that individuals with specific health issues or those currently pregnant cannot participate in this trial.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Are between the ages of 19-75.
• • Have blood pressure no higher than 150/90 mmHg.
• • Have a BMI below 35 Kg/m2 (otherwise healthy)
• • Free from metabolic disease (diabetes or renal disease), pulmonary disorders (e.g., COPD \& cystic fibrosis), and cardiovascular disease (peripheral vascular, cardiac, or cerebrovascular).
• • Do not have any precluding medical issues that prevent participants from exercising (i.e., cardiovascular issues, or muscle/joint issues including painful arthritis) or giving blood (e.g., blood thinners).
• • Are not currently smoking, using smokeless tobacco, nor smoked within the past 12 months.
• Exclusion Criteria:
• • Known allergy to MitoQ
• • High blood pressure - greater the 150/90 mmHg
• • Low blood pressure - less than 90/50 mmHg
• • History of cardiovascular disease
• • History of cancer
• • History of diabetes
• • History of kidney disease
• • Obesity (BMI \> 30 kg/m2)
• • Smoking or tobacco use
• • Current pregnancy
• • Nursing mothers
• • Communication barriers