UCSD Image-Guided Cognitive-Sparing Radiosurgery for Brain Metastases

Launched by JONA HATTANGADI-GLUTH · Apr 8, 2020

Keywords

ClinConnect Summary

This clinical trial, called "UCSD Image-Guided Cognitive-Sparing Radiosurgery for Brain Metastases," is studying a new way to treat brain tumors that have spread from other parts of the body, known as brain metastases. Researchers are using advanced imaging techniques to carefully target these tumors while protecting important areas of the brain that help with thinking and memory. The goal is to understand how this type of treatment affects brain function and to find ways to minimize any cognitive changes that might occur after treatment.

To participate, you need to be an adult aged 18 or older with one to three brain metastases that are smaller than 3 cm. You should be in relatively good health, with a performance status that indicates you can manage daily activities. Participants will need to be able to undergo MRI scans and give informed consent. If you are pregnant, have certain types of brain tumors, or are planning other treatments like chemotherapy, you may not be eligible. Those who join the trial can expect to receive specialized care and monitoring aimed at preserving their cognitive function while treating their brain tumors.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patients 18 years or older
• • 2. One to three brain metastases targets, all smaller than 3 cm in diameter (intact or resected tumor bed)
• • 3. Eastern cooperative Oncology Group (ECOG) performance status 0-2 (score of 0, no symptoms; 1, mild symptoms; 2, symptomatic, \<50% in bed during the day)
• • 4. Ability to answer questions and follow commands via neurocognitive testing
• • 5. Estimated life expectancy greater than 6 months
• • 6. Pathologic confirmation of extracerebral tumor site (eg, lung, breast, prostate) from either the primary site or a metastatic lesion
• • 7. Willingness/Ability to undergo brain MRI scans
• • 8. Able to give informed consent
• Exclusion Criteria:
• • 1. Pregnant or nursing women
• • 2. Women of childbearing potential unwilling to use adequate contraception
• • 3. Inability to complete a magnetic resonance imaging scan with contrast
• • 4. Tumor directly invading the critical area to be spared (for example a patient with tumor invading a critical white matter tract; ineligible for cognitive-sparing)
• • 5. Planned chemotherapy during SRS (on the day of SRS)
• • 6. Previous whole brain radiation therapy
• • 7. Leptomeningeal metastases (ineligible for SRS)
• • 8. Metastases from primary germ cell tumor, small cell carcinoma, or primary CNS lymphoma (ineligible for SRS)