Cerebrospinal Fluid Biomarkers in Bariatric Surgery

Launched by COLUMBIA UNIVERSITY · Apr 16, 2020

Keywords

ClinConnect Summary

This clinical trial is studying how bariatric surgery, a weight-loss surgery, helps people lose weight and keep it off. Researchers want to understand the changes that happen in the brain after surgery compared to changes that occur after losing weight through dieting. They will measure certain substances in the cerebrospinal fluid (the fluid around the brain and spinal cord) that are known to affect appetite and body weight. By comparing these measurements before and after surgery, as well as before and after diet-induced weight loss, the study aims to find out why bariatric surgery might be more effective than dieting alone.

To participate in this study, you need to be between 18 and 65 years old and have a body mass index (BMI) of 35 to 55, which indicates obesity. However, you cannot have any serious health issues, use tobacco, or have recently changed your weight by more than 5%. Participants will undergo tests and provide samples to help researchers learn more about the brain's role in weight loss. This research could lead to better treatment options for obesity in the future. If selected, you will be contributing to important discoveries that may benefit many people struggling with obesity.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 18-65 years old
• • BMI 35-55
• Exclusion Criteria:
• • No clinically significant medical conditions
• • No use of tobacco
• • No alcohol or drug abuse
• • No recent weight change (+/-5%) within prior 6 months
• • No medications that may affect body weight or blood glucose
• • No diabetes medications, beta-blockers, opiates or glucocorticoids
• • No pregnancy, breastfeeding, or planning to become pregnant during the study (diet group only)
• • No lactose intolerance