Exosome of Mesenchymal Stem Cells for Multiple Organ Dysfuntion Syndrome After Surgical Repaire of Acute Type A Aortic Dissection

Launched by FUJIAN MEDICAL UNIVERSITY · Apr 19, 2020

Keywords

ClinConnect Summary

This clinical trial is studying the use of special cells called mesenchymal stem cells, derived from umbilical cords, to help patients who develop multiple organ dysfunction syndrome (MODS) after surgery for a serious condition known as acute type A aortic dissection (ATAAD). MODS can happen when the body's organs start to fail after such a major surgery, and this trial aims to see if these stem cells can improve patients' health and recovery.

To be eligible for this study, participants must be over 60 years old and have undergone emergency surgery for ATAAD. They should also meet specific health criteria, such as having good oxygen levels and stable blood pressure before the surgery. For the second part of the trial, patients need to be experiencing failure in at least two organs. The trial is not yet recruiting participants, but if someone qualifies, they can expect to receive treatment with these stem cells and be closely monitored by healthcare professionals to assess their recovery. It's important to know that individuals with certain serious health issues or those who have had long-term steroid treatment may not be eligible for this study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• * Part 1:
• • Patients who are diagnosed with ATAAD and received emergency surgery with ascending aortic replacement combined with open placement of triple-branched stent graft
• • elder than 60 years old
• • Preoperative PaO2/FiO2 ≥ 400mmHg, platelets ≥ 150\*109/L, bilirubin≥ 20μmol/L, no hypotension (without vasoactive drugs), Glasgow Coma Score Scale = 15, creatine ≥110μmol/L
• Part 2:
• • Patients who are diagnosed with ATAAD and received emergency surgery with ascending aortic replacement combined with open placement of triple-branched stent graft
• • Patients who have failure of at least 2 organs
• * Patients who meet the criteria as below:
• • sequential organ failure assessment score (SOFA) ≥ 10
• Exclusion Criteria:
• • • uncontrollable underlying disease life expectancy of less than 4 days history of long-term corticosteroid use during the past 6 months.
• • The pre-operative computer tomography angiography(CTA) demonstrate the visceral arteries are involved
• • pre-existing severe disease of any major organs