The Acute Burn ResUscitation Multicenter Prospective Trial

Launched by AMERICAN BURN ASSOCIATION · Apr 20, 2020

Keywords

ClinConnect Summary

The Acute Burn ResUscitation Multicenter Prospective Trial is a study that aims to compare two different methods of giving fluids to adults who have suffered serious burn injuries. Specifically, the trial will look at whether using a combination of a type of fluid called colloid (which includes Lactated Ringer's solution and 5% Albumin) is more effective than using just crystalloid fluid (like Lactated Ringer's solution alone) for patients with burns covering at least 25% of their body. This study is currently recruiting participants, and they are looking for adults aged 18 and older who have experienced significant burns and are admitted to a burn center within 12 hours of their injury.

To be eligible for the trial, participants need to meet certain criteria, such as having a burn that is at least 25% of their total body surface area and a plan for receiving fluid treatment. Important to note, individuals with serious injuries from other trauma, specific types of electrical burns, or certain medical conditions (like severe kidney or liver disease) will not be able to participate. If you or a loved one is considering joining this study, you can expect to receive careful monitoring and care as part of the trial, contributing to important research that could improve treatment for burn injuries in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥ 18 years
• • Total burn size (second and third degree) is ≥ 25% of the TBSA
• • Burn center admission within 12 hours of injury.
• • There is a plan for formal fluid resuscitation.
• Exclusion Criteria:
• • Significant associated trauma
• • High voltage (≥ 1000 volts) electrical burns
• • Burn wound excision surgery within 48 hours from injury
• • Fresh frozen plasma (FFP) given at any time ≤ 48 hours from injury
• • Hypertonic saline (HTS) given at any time ≤ 48 hours from injury
• • Hydroxyethyl starch (HES) given at any time ≤ 48 hours from injury
• • High dose Vitamin C infusion given at any time ≤ 48 hours from injury
• • Administration of human albumin prior to randomization
• • Palliative comfort measures are instituted ≤ 48 hours from injury
• • Pregnancy
• • Pre-injury chronic renal insufficiency equal to or greater than stage 3
• • Pre-injury chronic hepatic disease (Child-Pugh B or C)
• • Pre-injury left ventricular (LV) dysfunction (echocardiography LV grade II-IV or ejection fraction ≤ 35%)