MRE Scan for the Assessment of Differences in Tissue Stiffness Between Radiation Necrosis and Recurrent Glioma in Patients With Previously Treated Gliomas

Launched by M.D. ANDERSON CANCER CENTER · Apr 30, 2020

Keywords

ClinConnect Summary

This clinical trial is studying a new imaging technique called magnetic resonance elastography (MRE) to help doctors understand the differences in tissue stiffness between two conditions that can occur after treatment for gliomas: radiation necrosis (damage caused by radiation) and recurrent glioma (the return of the tumor). By measuring how hard or soft the affected tissue is, researchers hope to improve diagnosis and treatment options for patients who have previously been treated for gliomas.

To participate in this trial, you must be at least 18 years old and have a confirmed diagnosis of an intracranial glioma that has been treated with chemotherapy and radiation. The area of concern in your brain needs to be larger than 2 centimeters. If you join the study, you can expect to undergo the MRE scan, which is a non-invasive procedure and does not involve surgery. However, certain conditions, like having a pacemaker or being pregnant, may prevent you from participating. This trial is currently recruiting participants, so if you meet the eligibility criteria, you may have the opportunity to contribute to important research that could lead to better care for patients with similar conditions.

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Eligibility criteria

• • Inclusion Criteria
• • \>/=18 years old.
• • History of a pathology proven intracranial glioma (including IDH mutant, IDH wildtype or 1p19q co-deleted tumors) treated with chemotherapy and radiation.
• • The lesion of concern (T2 Flair Hyperintense or contrast enhancing lesion) is \> 2 cm
• • Patient is able to understand and give consent to participation in the study.
• • Exclusion Criteria
• • Patients less than 18 years of age.
• • Pregnant.
• • Known allergy to gadolinium-based contrast agents.
• • Renal failure as evidenced by a glomerular filtration rate (GFR) of less than 30 mL/min/1.73m2.
• * Pacemakers, electronic stimulation, metallic foreign bodies and devices and/or other conditions that are not MR safe, which include but are not limited to:
• • electronically, magnetically, and mechanically activated implants
• • ferromagnetic or electronically operated active devices like automatic cardioverter defibrillators and cardiac pacemakers
• • metallic splinters in the eye
• • ferromagnetic hemostatic clips in the central nervous system (CNS) or body
• • cochlear implants
• • other pacemakers, e.g., for the carotid sinus
• • insulin pumps and nerve stimulators
• • non-MR safe lead wires
• • prosthetic heart valves (if dehiscence is suspected)
• • non-ferromagnetic stapedial implants
• • claustrophobia that does not readily respond to oral medication