Driving Pressure in Laparoscopic Surgery

Launched by CAPITAL MEDICAL UNIVERSITY · Apr 30, 2020

Keywords

ClinConnect Summary

After screened for preoperative risk factors, 48 patients undergoing elective laparoscopic surgery and planned to be extubated in the operating room are randomly assigned to two groups: (1) PEEP = 5cmH2O; (2) driving pressure (DP)-guided PEEP. The ventilation protocol consists of volume-controlled mechanical ventilation (Datex Ohmeda S/5 Advance; General Electric Company Healthcare, Helsinki, Finland) at a tidal volume (VT) of 8 ml/kg predicted body weight (PBW), fresh gas of 2 litre /min, inspiratory to expiratory ratio of 1:2, and a respiratory rate adjusted to normocapnia (arterial carbo...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Informed consent has been obtained
• • Elective laparoscopic surgery with Trendelenburg position
• • Expected ventilation duration \> 2 hours
• • Scheduled to be extubated in the operation
• Exclusion Criteria:
• • Mechanical ventilation of \> 1 hour within the last 2 weeks before surgery
• • Body mass index ≥ 35 kg/m2
• • Acute respiratory failure (pneumonia, acute lung injury or acute respiratory distress syndrome)
• • Emergency surgery
• • Severe cardiac disease
• • Progressive neuromuscular illness
• • Pregnancy
• • Refusal to participate
• • Contradicted to EIT scan