Learning Mechanisms for Placebo and Nocebo Studies on Somatosensory Sensations: a Systematic Review and Meta-analysis.

Launched by LEIDEN UNIVERSITY MEDICAL CENTER · May 11, 2020

Keywords

ClinConnect Summary

Research questions include:

1. What is the average magnitude of placebo or nocebo effects on pain and on itch, across included studies?
2. Across studies that tested multiple learning processes for placebo and nocebo effects on pain, is the magnitude of a placebo or nocebo effect on pain different based on the learning process used to induce the effect?
3. Does the magnitude of placebo or nocebo effects differ between the sensations of pain and itch?
4. Are nocebo effects on pain and itch stronger than placebo effects on pain and itch, as measured by their relative magnitude?

Dependent up...

Gender

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Eligibility criteria

• Inclusion Criteria:
• • Studies using experimental induction of placebo and/or nocebo effects on somatosensory sensations (i.e., pain and/or itch), which necessitates the (supposed) administration of an inert treatment, which, through a given learning process, is believed to have positive or negative effects.
• • This review will include original, controlled experimental studies on healthy participants that employed learning-based inductions of placebo and/or nocebo effects on somatosensory sensations. The studies should be written in English, German or Dutch, available full-text, and published in a peer-reviewed journal. No year restrictions on publication date will be imposed.