The Microbiota in Kidney Donation and Transplantation

Launched by ROYAL FREE HOSPITAL NHS FOUNDATION TRUST · May 12, 2020

Keywords

ClinConnect Summary

This clinical trial is investigating how the bacteria and microorganisms in our bodies, particularly in the gut and urinary tract, affect the immune system and overall health after a kidney transplant. Researchers want to understand if changes in these microbial communities can lead to complications after the transplant, such as rejection of the new kidney or infections. By studying participants before and up to one year after their transplant, the team hopes to find connections between these microbial changes and patient outcomes.

To participate, you need to be an adult (18 years or older) who is either a living kidney donor or a recipient waiting for a kidney transplant that matches your blood group. You should be willing to provide samples of urine, blood, and stool for the study. If you join, you can expect to have regular follow-up visits, where your health and the status of your transplant will be monitored alongside the changes in your microbiota. This research could help improve kidney transplant outcomes in the future by better understanding the role of microbes in our bodies.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • All adult (≥18 years old) undergoing living donor nephrectomy or kidney transplantation. Patients willing to provide samples including Urine, Blood, Faecal samples.
• • 1. Participant able to give Informed Consent
• • 2. All patients will be at least 18 years old
• • 3. Patients will either be a live renal transplant donor or a renal transplant recipient on the waiting list to have or will have had an ABO-blood group compatible renal transplant.
• • 4. Patients attending hospital clinics at participating centre for routine clinical follow -up.
• • 5. Patients willing to comply with study procedures and willing to provide blood, faecal and urine samples.
• Exclusion Criteria:
• • 1. Patients under the age of 18 years
• • 2. Patients unable to give informed consent
• • 3. Patients not able to comply with study procedures or follow-up visits
• • 4. Patients that are not a live renal donor or that are not on the waiting list to have or have not had an ABO blood group compatible renal transplant and are not attending hospital outpatient clinics at participating study centres for routine clinical follow-up.