Assessment of the Relationship Between Cerebral Blood Flow and Heart Rate

Launched by UNIVERSITY OF CALGARY · May 14, 2020

Keywords

ClinConnect Summary

This clinical trial is studying how heart rate affects blood flow in a specific part of the brain called the middle cerebral artery (MCA). Researchers want to understand the connection between how fast the heart beats and how well blood flows through this artery, which is important for brain health. To do this, they will recruit patients who are already scheduled for certain heart procedures. During these procedures, doctors will use a temporary device to control the heart rate while measuring blood flow in the MCA with a special ultrasound.

To participate in this study, you need to be between 18 and 70 years old and scheduled for a heart procedure where a device will be placed in your heart. You should also have a good heart function, as indicated by a measurement called left ventricular ejection fraction. If you join the trial, you can expect to have your heart rate adjusted during the procedure while researchers monitor your blood flow. It’s important to note that participants must be able to give their consent and travel to the Cardiac Electrophysiology Laboratory in Calgary, Canada.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Male or female
• • Age 18-70 years, inclusive
• • Scheduled for clinically indicated elective electrophysiological studies where temporary pacing catheters are being placed in the right atrium
• • Left ventricular ejection fraction ≥50%
• • Able and willing to provide informed consent
• • Able to travel to the Cardiac Electrophysiology Laboratory at the Foothills Medical Centre, Calgary, Alberta, Canada
• Exclusion Criteria:
• • Unable or unwilling to provide informed consent
• • Other factors which in the investigator's opinion would prevent the participant from completing the protocol