Intraoperative Mechanical Ventilation and Postoperative Pulmonary Complications After On-pump Cardiac Surgery in High-risk Patients

Launched by RENNES UNIVERSITY HOSPITAL · May 25, 2020

Keywords

ClinConnect Summary

This clinical trial is studying the effects of two different ways of using mechanical ventilation (a machine that helps patients breathe) during heart surgery. The goal is to find out which method leads to fewer breathing problems after surgery for patients who are at high risk for these complications. While it's common to use low tidal volumes (the amount of air delivered to the lungs), there is still debate about the best settings for pressure in the lungs and whether certain techniques to open the airways should be used.

To participate in this trial, patients need to be over 18 years old and scheduled for heart surgery, such as bypass surgery or valve replacement. They should have a higher risk for lung issues, as indicated by a specific scoring system. However, patients with certain conditions, like obesity or severe heart issues, may not be eligible. Those who join the study can expect to receive one of the two ventilation methods during their surgery, and their recovery will be monitored to see how well they do afterward. It's important for potential participants to know that they will need to give permission to be part of this study and that their safety and well-being will be a top priority throughout the process.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients older than 18 years-old,
• • Evaluated before cardiopulmonary bypass for any cardiac surgical procedure (e.g. coronary artery bypass grafting, valve, aorta, or combined procedures),
• • With a pulmonary risk score ≥ 2
• • Who gave written informed consent
• • affiliated to a social security system
• Exclusion Criteria:
• • BMI \> 40kg/m2 ;
• • Left Ventricular Ejection Fraction \< 35% ;
• • Preoperative shock ;
• • Aortic surgery with planned circulatory arrest ;
• • Minimally invasive cardiac surgery ;
• • Emergency surgery with patient unable to give written informed consent
• • Heart transplantation
• • Mechanical circulatory support surgery
• • Pregnant or lactating women
• • Adults legally protected (under judicial protection, guardianship, or supervision), persons deprived of their liberty