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Phase 1/2 Clinical Trial of LY3884963 in Patients With Frontotemporal Dementia With Progranulin Mutations (FTD-GRN)

Launched by PREVAIL THERAPEUTICS · May 28, 2020

Trial Information

Current as of July 22, 2025

Recruiting

Keywords

Fronto Temporal Dementia Frontotemporal Dementia Progranulin Mutations Ftd Grn Gene Therapy Dementia Gene Therapy Aav9

ClinConnect Summary

This clinical trial, called the J4B-MC-OKAA study, is testing a new treatment called LY3884963 for patients with frontotemporal dementia (FTD) who have a specific genetic mutation known as progranulin (GRN) mutation. The trial aims to learn if this treatment is safe and if it can help increase levels of a protein called progranulin, which is important for brain health. The study will involve different groups of patients receiving either low or medium doses of the treatment, and it will last for a total of five years. During the first year, patients will be closely monitored for safety and how well the treatment works.

To participate in this trial, individuals need to be between 30 and 85 years old and have a diagnosed case of symptomatic frontotemporal dementia. They must also carry a pathogenic progranulin gene mutation and be able to provide informed consent, meaning they understand the study's purpose and risks. Participants will not only be monitored during the first year but will also follow up for four additional years to keep track of their health and any changes related to the treatment. It's important to note that certain health conditions or treatments may prevent someone from being eligible for the study, so a thorough screening will be conducted.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Men or women aged 30 to 85 years (inclusive), at the time of informed consent.
  • Body weight range of ≥40 kg (88 lbs) to ≤110 kg (242 lb) and a BMI of 18 to 34 kg/m2.
  • Has symptomatic frontotemporal dementia (FTD), including mild behavioral, cognitive, motor or language impairment per Investigator's assessment (behavioral-variant FTD, primary progressive aphasia-FTD, FTD with corticobasal syndrome, or a combination of syndromes are allowed for enrollment).
  • Score ≥0.5 and ≤15 on CDR plus NACC FTLD sum of boxes.
  • Stable use of background medications at least 8 weeks prior to LY3884963 dosing.
  • Carrier of a pathogenic progranulin gene (GRN) mutation.
  • Negative screening test for Mycobacterium tuberculosis (MTB) or documented negative MTB test within 1year prior to screening.
  • Age- and gender-appropriate cancer screenings are up-to-date and completed.
  • Patient and/or patient's legally authorized representative has the ability to understand the purpose and risks of the study, and provide written informed consent and authorization to use protected health information.
  • Patient has a reliable study partner/informant (e.g. family member, friend) willing and able to participate in the study as a source of information on the patient's health status and cognitive and functional abilities.
  • Patient is not dependent on a walker or wheelchair.
  • Patient is living in the community (i.e. not in nursing home); some levels of assisted living may be permitted at the discretion of the investigator.
  • Pneumococcal pneumonia and shingles vaccines are required within 10 years of Screening (allowed to be performed during Screening but must be given at least 4 weeks prior to initiation of immunosuppressant regimen).
  • Exclusion Criteria:
  • Diagnosis of a significant CNS (central nervous system) disease other than frontotemporal dementia (FTD) that may cause FTD symptoms or confound study objectives.
  • Brain or cervical spine magnetic resonance image (MRI)/MRA imaging showing clinically significant abnormality considered to prevent intracisternal magna (ICM) injection.
  • Hypersensitivity or contraindications to corticosteroid, and/or sirolimus use.
  • Clinical evidence of peripheral symmetric sensory polyneuropathy (stable sensory mononeuropathies and radiculopathies are not exclusionary).
  • Concomitant disease or condition within 6 months of screening that could interfere with, or treatment of which might interfere with, the conduct of the study or that would, in the opinion of the investigator, pose an unacceptable safety risk to the patient or interfere with the patient's ability to comply with study procedures
  • Clinically significant laboratory test result abnormalities assessed at screening.
  • Participation within 3 months prior to screening in another therapeutic investigational drug or device study with purported disease-modifying effects on FTD, unless it can be documented that the patient received placebo only.
  • Any type of prior gene or cell therapy.
  • Live vaccines in the 4 weeks prior to Screening. NOTE: Pneumococcal vaccine and/or shingles vaccine administration is allowed at least 4 weeks prior to initiation of immunosuppressant regimen.
  • Use of blood thinners in the 2 weeks prior to screening, or anticipated use of blood thinners during the study. Antiplatelet therapies are acceptable if the patient is medically able to temporarily stop 48 hours to 7 days (depending on the antiplatelet medication used) prior to and at least 48 hours after ICM injection and LP. Note: the use of blood thinners as part of prophylaxis or treatment of an emergent VTE or another AE during the study does not exclude the patient, unless there is a baseline high risk of thromboembolic events, and use of blood thinners is highly anticipated in the opinion of the Investigator.
  • Contraindications or intolerance to imaging methods (MRA, MRI, and/or computed tomography \[CT\]), including claustrophobia and intolerance to contrast agents used for MRI, MRA, or CT (including, but not limited to, gadolinium contrast agents and iohexol).
  • Contraindications to general anesthesia or deep sedation.
  • Positive urine test for drugs of abuse (including opiates, amphetamines, cocaine, barbiturates, and phencyclidine) without prescription at Screening and on Day 1.
  • Other protocol-defined inclusion/exclusion criteria may apply

About Prevail Therapeutics

Prevail Therapeutics is a biopharmaceutical company focused on developing innovative gene therapies for neurodegenerative diseases. With a commitment to addressing unmet medical needs, Prevail leverages advanced genetic engineering techniques to create targeted treatments aimed at halting or reversing the progression of conditions such as Parkinson's disease. The company's expertise in neurology and gene therapy positions it at the forefront of research and development, as it strives to improve the quality of life for patients through groundbreaking therapeutic solutions.

Locations

Orlando, Florida, United States

Philadelphia, Pennsylvania, United States

Camperdown, New South Wales, Australia

Leuven, , Belgium

Barcelona, , Spain

San Sebastian, , Spain

London, , United Kingdom

Paris, , France

Orlando, Florida, United States

Maitland, Florida, United States

Saint Pierre, Marseille, France

Lille, , France

Patients applied

0 patients applied

Trial Officials

Olga Uspenskaya-Cadoz, MD, PhD

Study Director

Prevail Therapeutics

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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