DreaMS - Digital Biomarkers for Multiple Sclerosis

Launched by RESEARCH CENTER FOR CLINICAL NEUROIMMUNOLOGY AND NEUROSCIENCE BASEL · May 29, 2020

Keywords

ClinConnect Summary

Multiple Sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) causing focal lesions of demyelination and diffuse neurodegeneration in the grey and white matter of the brain and spinal cord, leading to physical and cognitive disability. Currently there is a limited number of relevant biomarkers available in patients with MS, such as clinical, imaging or biological measures. Patient history and neurologic examination in combination with magnetic resonance imaging (MRI), evoked potentials and analysis of serum and cerebrospinal fluid (CSF) are the gold standard ...

Gender

ALL

Eligibility criteria

• • Patients with MS
• Inclusion Criteria:
• • Age 18-70
• • Diagnosed with MS according to the revised McDonald criteria 2017, all clinical forms inclusive (CIS, RRMS, SPMS, PPMS)
• • EDSS ≤ 6.5
• • In possession of a smart phone
• Exclusion Criteria:
• • Age \<18 and \> 70
• • EDSS \> 6.5
• • Other clinically significant concomitant disease states (e.g., renal failure, severe hepatic dysfunction, severe/unstable cardiovascular disease, progressive cancer, etc.)
• • Known or suspected non-compliance, drug or alcohol abuse
• • Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc.
• • Women who are pregnant or breast feeding
• • Not in possession of a smart phone
• • Healthy Volunteers
• Inclusion Criteria:
• • Age 18-70
• • In possession of a smart phone
• Exclusion Criteria:
• • Age \<18 and \> 70
• • Diagnosis of MS
• • Clinically significant concomitant disease states (e.g., renal failure, severe hepatic dysfunction, severe/unstable cardiovascular disease, progressive cancer, etc.)
• • Known or suspected non-compliance, drug or alcohol abuse
• • Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc.
• • Women who are pregnant or breast feeding
• • Not in possession of a smart phone