Interest of Individual Biomarkers From the Identification of Tumor Genotype by High-throughput Molecular Techniques

Launched by CENTRE HOSPITALIER UNIVERSITAIRE DIJON · Jun 2, 2020

Keywords

ClinConnect Summary

This clinical trial is studying how certain blood markers, specifically tumor DNA (ctDNA), can help doctors better manage treatment for patients with lymphomas, which are a type of cancer affecting the blood. The focus is on three common types of lymphomas: diffuse large B-cell lymphoma (DLBCL), Hodgkin's lymphoma (HL), and follicular lymphoma (FL). Researchers hope that by analyzing ctDNA alongside PET scans (a type of imaging test), they can identify how well patients are responding to treatment, adjust therapies if needed, and potentially catch relapses earlier than current methods allow.

To be eligible for this trial, participants must be diagnosed with one of the three lymphoma types and not currently undergoing treatment. They should also have PET scan images available for review. Participants will provide blood samples before treatment, during treatment, and for two years afterward, allowing researchers to track how ctDNA levels change. This study aims to improve personalized care for future lymphoma patients by learning from the experiences of those involved in the trial.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Person who has not opposed to their inclusion in the trial
• • Confirmation of the diagnosis of one of the lymphomas (DGLBL, LF, classic LH, LT or LCM) according to the WHO 2016 international classification (Smerdlow et al, 2016)
• • Patients not currently taking treatment for their haemopathy (or who have received corticosteroid therapy alone within 14 days prior to the 1st sampling, dose limited to 500mg total)
• • Patients requiring systemic treatment within 30 days of screening
• Exclusion Criteria:
• • Person subject to legal protection (curatorship, guardianship)
• • Person under partial judicial control
• • Pregnant, parturient or breastfeeding woman
• • Adult incapable or incapable to express his or her non-opposition
• • Minor
• • Localized lymphoma treated by surgery and/or localized radiotherapy