Clinical and Genetic Analysis of ROP

Launched by OREGON HEALTH AND SCIENCE UNIVERSITY · Jun 4, 2020

Keywords

ClinConnect Summary

This clinical trial is studying Retinopathy of Prematurity (ROP), a condition that affects the eyes of premature infants and can lead to blindness if not treated early. The goal of the research is to gather information about ROP by looking at both clinical data (like routine eye exam results) and genetic information. This study will help doctors understand ROP better and improve care for affected infants. Researchers will recruit infants from various neonatal intensive care units (NICUs) who need ROP screenings as part of their regular care.

To be eligible for the trial, infants must be hospitalized in one of the participating NICUs and meet specific guidelines for needing an eye exam. They will not be enrolled if they have certain eye issues or are too unstable for an exam. If families choose to participate, their babies will have routine eye exams that include taking retinal photographs to collect important information. These photographs are standard practice and do not include personal details about the infants. Ultimately, this research aims to create a better framework for understanding and treating ROP, benefiting future generations of premature infants.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • All infants hospitalized at participating Neonatal Intensive Care Units will be eligible for the study if they meet plublished criteria for requiring ROP screening examination, or if they are transferred to the study center for specialized ophthalmic care. These eligibility criteria are identical at each study center, and match what is done in standard clinical practice according to national guidelines published jointly by the American Academy of Pediatrics, American Academy of Ophthalmology, and American Associatioin for Pediatric Ophthalmology and Strabismus (AAP-AAO, Pediatrics, 2013).
• Exclusion Criteria:
• • Patients will be excluded if they have structural ocular anomalies, or if they are considered unstable for examintion by their attending neonatologist.