Diffusion Basis Spectrum Imaging of the Prostate

Launched by WASHINGTON UNIVERSITY SCHOOL OF MEDICINE · Jun 3, 2020

Keywords

ClinConnect Summary

This clinical trial is studying a new imaging test called Diffusion Basis Spectrum Imaging (DBSI) that could help detect prostate cancer earlier and more accurately. This test is non-invasive, meaning it doesn't require any surgery or incisions, making it a safer option for identifying clinically significant prostate cancer. The trial is looking for men aged 18 and older who are either planning to have a prostate biopsy for the first time or who have been diagnosed with prostate cancer and are actively monitoring their condition.

To participate, candidates must be in good health and willing to give their consent. However, men with certain medical conditions, like those who have metal implants or severe claustrophobia, may not be eligible for the study. Participants will undergo the DBSI imaging test and may be asked to provide information about their health and experiences. This trial aims to improve the way prostate cancer is detected, potentially leading to better outcomes for patients.

Gender

MALE

Eligibility criteria

• Inclusion Criteria:
• • Over 18 years of age and willing and able to provide informed consent.
• • Patients with no prior diagnosis of prostate cancer, who are planning to undergo prostate biopsy as clinical standard of care ("early detection cohort")
• * Including those men with:
• • an elevated PSA and no prior biopsy
• • an elevated PSA and a negative prior biopsy
• • Patients with a prior diagnosis of prostate cancer, who are currently managed with active surveillance, who are planning to undergo biopsy as clinical standard of care ("active surveillance cohort")
• Exclusion Criteria:
• • Patients with any clinical contraindication to MRI
• \*Including but not limited to:
• • Those with metallic implants, such as pacemakers or implantable cardioverter-defibrillators
• • Those with cochlear implants
• • Those with claustrophobia not relieved with medications (patients with claustrophobia who do not need medications for the scan or whose claustrophobia can be managed with medication, are eligible to participate)
• • Those who cannot lie flat for over 1 hour
• • Patients with prior prostate surgery for prostate cancer (e.g. radical prostatectomy, focal ablation)