Study of Pathophysiology of Status Epilepticus and Dysimmune Encephalitis
Launched by ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS · Jun 4, 2020
Trial Information
Current as of July 25, 2025
Recruiting
Keywords
ClinConnect Summary
The COLETTE study is researching severe brain conditions called status epilepticus and dysimmune encephalitis. These conditions can cause prolonged seizures and other serious neurological problems. The goal of the study is to collect blood, cerebrospinal fluid (the fluid surrounding the brain and spinal cord), and tissue samples from patients with these conditions, as well as from healthy individuals. This will help researchers understand what causes these disorders and how they affect the brain.
To participate, patients must be at least 2 years old and either have status epilepticus or epilepsy related to dysimmune encephalitis. They should also be part of the French social security system and provide consent to join the study. Participants can expect to undergo tests that involve the collection of samples, which will be used to advance knowledge about these conditions. It’s important to note that pregnant women and certain patients with specific medical issues cannot take part in the study. This research aims to improve our understanding of these serious conditions and could potentially lead to better treatments in the future.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- Group 1:
- • Patients aged 2 years or above, with status epilepticus.
- • Affiliation to a French social security system excluding "Aide Médicale" Etat (AME).
- • Patients or relatives have been informed and given free informed and written consent to participate
- • Patients under legal protection (guardianship, curatorship) or not
- Group 2:
- • Patients aged 2 years or above, with clinical signs of epilepsy associated to dysimmune encephalitis.
- • Affiliation to a French social security system excluding "Aide Médicale" Etat (AME).
- • Patients or relatives have been informed and given free informed and written consent to participate
- • Patients under legal protection (guardianship, curatorship) or not
- Group 3:
- • Patients aged 18 years or above, without status epilepticus and/or dysimmune encephalitis.
- • Affiliation to a French social security system excluding "Aide Médicale" Etat (AME).
- • Patients or relatives have been informed and given free informed and written consent to participate
- • Patients under legal protection (guardianship, curatorship) or not
- Exclusion Criteria:
- Group 1:
- • Women with known or clinically detected pregnancy.
- • Patient deprived of liberty
- • Patients with known neurodegenerative disease.
- Group 2:
- • Women with known or clinically detected pregnancy.
- • Patient deprived of liberty
- • Patients have been already treated by corticoids or IgIV.
- Group 3:
- • Women with known or clinically detected pregnancy.
- • Patient deprived of liberty.
- • Patients with status epilepticus.
- • Patients with known neurodegenerative disease, brain tumor, severe head trauma, meningitis, subarachnoid hemorrhages, stroke.
About Assistance Publique Hôpitaux De Paris
Assistance Publique - Hôpitaux de Paris (AP-HP) is a leading public hospital system in France, renowned for its commitment to healthcare excellence and innovative medical research. As a prominent clinical trial sponsor, AP-HP plays a pivotal role in advancing medical knowledge and improving patient care through rigorous scientific investigations across a wide range of therapeutic areas. With a focus on collaboration and interdisciplinary approaches, AP-HP leverages its extensive network of hospitals and expert clinicians to facilitate high-quality clinical trials that adhere to the highest ethical and regulatory standards, ultimately aiming to translate research findings into tangible health benefits for diverse patient populations.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Paris, , France
Patients applied
Trial Officials
Vincent NAVARRO, Pr
Principal Investigator
Hôpital Pitié Salpêtrière - Assitance Publique Hôpitaux de Paris
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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