Microwave Ablation or Wedge Resection for the Treatment of Lung, Sarcoma and Colorectal Lesions, ALLUME Study

Launched by M.D. ANDERSON CANCER CENTER · Jun 10, 2020

Keywords

ClinConnect Summary

The ALLUME Study is a clinical trial that aims to find out which treatment works better for patients with certain types of cancer that have spread to other areas of the body, specifically lung cancer, sarcoma, and colorectal cancer. The study compares two common procedures: microwave ablation, which uses heat to kill cancer cells, and wedge resection, where a small piece of lung tissue containing the tumor is surgically removed. By comparing these two options, researchers hope to determine which method is safer and more effective for treating these cancers.

To be eligible for this trial, participants should have a lung tumor that is 3 centimeters or smaller and must meet other specific health criteria. For example, the tumor must either be confirmed as cancer through a biopsy or show growth on imaging tests. Those with serious health issues or who are pregnant or breastfeeding are not eligible. Participants in the trial can expect to undergo one of the two procedures and will be monitored closely for outcomes and side effects. This research is important as it may lead to better treatment options for patients facing these challenging cancers.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patient has a lung lesion(s) that is either biopsy-proven cancer or shows sequential growth on CT imaging with clinical suspicion for non-small cell lung cancer (NSCLC)-stage I; NSCLC-stage \> 1; metastatic sarcoma; or metastatic colorectal (CRC) cancer
• • 3 cm or less tumor size
• • Other sites for cancer are either controlled or there are plans for control
• • Expected margin at least 1 cm from critical structures, allowing for protective strategies such as induction of therapeutic pneumothorax. Critical structures include the trachea, main bronchi, esophagus, aorta, aortic arch branches, superior vena cava (SVC), main, right or left pulmonary artery, or heart.
• Exclusion Criteria:
• • Patient is considered high risk for ablation due to major comorbid medical conditions
• • Patient is pregnant or breast feeding