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Search / Trial NCT04432285

Long-term Outcome of DBS Versus Botulinum Toxin Treatment in Cervical Dystonia

Launched by OSLO UNIVERSITY HOSPITAL · Jun 12, 2020

Trial Information

Current as of July 24, 2025

Enrolling by invitation

Keywords

Deep Brain Stimulation Botulinum Toxin Treatment

ClinConnect Summary

Cervical dystonia (CD) is the most common isolated dystonia in adults, with a prevalence of 9-13/100000. CD has a mean age at onset of 40 years, and is almost twice as common in women than in men. Cervical dystonia symptoms can in most patients be managed well by botulinum toxin (BoNT) injections, and supporting treatment measures. However, one-fifth to one-third of patients do not obtain sufficient relief from long-term BoNT therapy, resulting in reduced quality of life. Deep brain stimulation in the postero-ventral part of the internal globus pallidus (GPi-DBS) has been established as an ...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • DBS-group: Patients with isolated cervical dystonia (focal or part of segmental dystonia) who have been operated at Oslo University between June 2004 and June 2017 and treated with bilateral GPi-DBS for a minimum of 3 years, and who give their informed consent to participate in this follow-up study.
  • BoNT-group: Patients who are receiving regular BoNT-injections at Oslo University Hospital for isolated cervical dystonia (focal or part of segmental dystonia), who are gender-and age-matched to the operated patients, and who give their informed consent to participate in this follow-up study.
  • Exclusion Criteria:
  • Dementia/inability to respond to the CDIP-58.

About Oslo University Hospital

Oslo University Hospital is a leading academic medical center in Norway, renowned for its commitment to advancing healthcare through innovative research and clinical trials. As a prominent sponsor of clinical studies, the hospital integrates cutting-edge scientific inquiry with patient care, fostering an environment that promotes the development of new therapies and treatment strategies. With a multidisciplinary approach, Oslo University Hospital collaborates with various stakeholders, including researchers, healthcare professionals, and industry partners, to enhance clinical outcomes and contribute to the global medical community. Its dedication to ethical standards and patient safety ensures that all trials are conducted with the highest level of integrity and respect for participant welfare.

Locations

Oslo, , Norway

Patients applied

0 patients applied

Trial Officials

Inger Marie Skogseid, MDPhD

Study Director

Oslo University Hospital

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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