Individual Cerebral Hemodynamic Oxygenation Relationships

Launched by MATTHEW BORZAGE · Jun 16, 2020

Keywords

ClinConnect Summary

This clinical trial is investigating how two different types of anesthesia, propofol and sevoflurane, affect blood flow and oxygen use in the brain during an MRI scan. The goal is to see if there are any notable differences between these two anesthetics when used in patients who require anesthesia for their MRI. If you or your child are scheduled for an MRI and need anesthesia, you may be eligible to participate in this study.

To take part, you need to be scheduled for an MRI and able to tolerate the procedure. It’s important that you do not have any serious medical conditions that could affect how your brain uses oxygen or blood flow, and you shouldn’t have any devices that are incompatible with MRI machines. If you choose to participate, you will be randomly assigned to receive either propofol or sevoflurane, which means you won’t know in advance which one you will get. Before joining the trial, you will be asked to sign a consent form to ensure you understand what participation involves. Your safety and comfort are the top priorities throughout the study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients who are scheduled for a clinically indicated MRI at the sponsor institution.
• • Patients who are able to tolerate an MRI.
• • Patients who require clinical anesthesia for their MRI.
• • Patients with conditions not believed to alter oxygen metabolism or blood flow in the brain, including but not limited to patients with orthopedic indications, undescended testicles, hernia repairs, term equivalent age scans.
• • Patients who have no medical conditions that make the use of propofol or sevoflurane better for their clinical outcome.
• • Patients between birth and up-to 1 year of age.
• • Patients with conditions known to alter oxygen metabolism or blood flow in the brain, e.g. traumatic brain injury, hypoxic ischemic encephalopathy, tumor.
• Exclusion Criteria:
• • Patients with an MRI-incompatible device or implant (e.g. pacemakers, stents)
• • Preterm infants less than 25 weeks postmenstrual age (PMA) at the time of the scan.
• • Patients who are clinically too unstable to extend their MRI by up-to 10 minutes.
• • Patients who do not require clinical anesthesia.
• • Patients at risk for propofol infusion syndrome (known severe metabolic acidosis, hyperkalemia, lipemia, rhabdomyolysis, hepatomegaly, renal failure, ECG ST segment elevation, and/or cardiac failure)
• • Patients at risk for sevoflurane-based malignant hyperthermia (known ryanodine receptor mutations)
• • Patient at risk for sensitivity to volatile halogenated anesthetic agents (known congenital Long QT Syndrome or patients taking drugs that can prolong the QT interval),
• • Patients with Perioperative Hyperkalemia (known neuromuscular disease, particularly Duchenne muscular dystrophy)