Antibiotic Dosing in Geriatric Patients At the Emergency Department

Launched by UNIVERSITY HOSPITAL, GHENT · Jun 16, 2020

Keywords

ClinConnect Summary

This clinical trial is studying how well certain antibiotics work in older patients who are admitted to the geriatric department after visiting the emergency room. Specifically, the researchers want to find out if the current doses of antibiotics, like Amoxicillin-Clavulanate and Piperacillin-Tazobactam, are effective for frail elderly patients. This group is particularly important since older adults often have different health needs and responses to medications.

To take part in this study, patients need to be at least 75 years old and have certain health assessments showing they are frail. Participants will receive antibiotics through an intravenous (IV) line, and their blood will be sampled to see how well the antibiotics are reaching the target levels in their bodies. It's important to note that patients who have a known allergy to these antibiotics or who are being treated in other hospital units won't be included in this trial. Overall, this study aims to improve antibiotic treatment for older individuals, ensuring they receive the best possible care during their hospital stay.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients presenting at the emergency department and later on admitted to the geriatric department
• • Patient age 75 years or older
• • Patients with geriatric profile according to KATZ scale, G8 screening test or CIRS score.
• • Patient receiving antibiotic treatment (amoxicillin-clavulanate, piperacillin-tazobactam)
• • Intravenous access available for blood sampling. For measurement of the peak concentration an intravenous access other than the drug infusion line is required.
• Exclusion Criteria:
• • Admission to other units than the geriatric department incl. the ICU.
• • Absence of informed consent
• • Known hypersensitivity to beta-lactam antibiotics
• • Patients who received oral amoxicillin-clavulanate prior to admission will not be included in the iv. amoxicillin-clavulanate group.