Renal Metabolism of Glycolate to Oxalate

Launched by UNIVERSITY OF ALABAMA AT BIRMINGHAM · Jun 16, 2020

Keywords

ClinConnect Summary

This clinical trial is studying how the body processes a substance called glycolate and how this affects the amount of oxalate found in urine. Oxalate is a compound that can form kidney stones, so understanding its metabolism in healthy individuals is important. The researchers will use a special technique with a carbon isotope and have participants follow a low-oxalate diet to see how these factors influence oxalate levels in urine.

To be eligible for this trial, participants need to be healthy adults aged between 18 and 75 years, with a body mass index (BMI) between 19 and 40. They should be able to understand the study details and provide consent. Participants will need to collect their urine for 24 hours on two occasions for screening. It’s important to note that individuals with certain medical conditions, or those who are pregnant or breastfeeding, cannot participate. If you join this study, you will contribute to important research that might help improve our understanding of kidney health.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Mentally competent adults, able to read and comprehend the consent form
• • 18-75 years of age
• • Body Mass Index (BMI) between 19 and 40
• • In good health as judged from a medical history, reported medications, and a complete blood metabolic profile
• • Acceptable 24 hour urine collections (performed twice for screening)
• Exclusion Criteria:
• • History of any hepatic, renal, bowel, or endocrine disease or any other condition that may influence the absorption, transport or urine excretion of ions
• • Abnormal urine chemistries or blood metabolic profiles
• • Poor 24 hour urine collections completed during screening, judged by 24 hour urine creatinine excretion (indicative of not collecting all urine in the 24 hour period)
• • Pregnancy, intention to become pregnant in the near future, or lactation
• • Aged \<18 or \>75
• • BMI \<19 or \>40