Is the BAT Inhibition Able to Replace Sting Challenges? (BATIRS)

Launched by MEDICAL UNIVERSITY OF GRAZ · Jun 16, 2020

Keywords

ClinConnect Summary

The clinical trial titled "Is the BAT Inhibition Able to Replace Sting Challenges?" (BATIRS) is investigating a new way to monitor patients with wasp and honeybee venom allergies. Insect venom allergies can lead to serious reactions, including breathing problems and even heart issues. Currently, the best way to see if a patient is still at risk for these severe reactions is through a test that uses live insects, which isn't available in many places. This study aims to see if a blood test, called the basophil activation test (BAT), can be a reliable alternative to this method. By measuring how certain immune cells respond to venom, doctors hope to determine whether patients are still at risk for allergic reactions.

To participate in this study, individuals must be between 18 and 70 years old and have been receiving or completed treatment with venom immunotherapy. Participants will undergo sting challenges and provide blood samples for the BAT tests. The study will include around 219 patients, and the findings could help doctors better monitor treatment effectiveness and quickly identify patients who may need adjustments in their therapy to prevent future allergic reactions. If successful, this approach could make it easier for more patients to receive the care they need.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Legally competent male and female subjects who are currently treated or who have been treated with vespid venom immunotherapy
• • Age ≥18 and ≤70 years
• • Written consent of the participant after being informed
• Exclusion Criteria:
• • Pregnancy
• • Autoimmune disease
• • Uncontrolled cardiovascular disease
• • Uncontrolled asthma