Autonomic Regulation of Blood Pressure in Premature and Early Menopausal Women

Launched by UNIVERSITY OF MINNESOTA · Jun 17, 2020

Keywords

ClinConnect Summary

This clinical trial is studying how menopause, especially when it happens earlier than usual, affects blood pressure and the body's automatic control of blood pressure in women. Researchers want to learn more about how menopause influences these factors in both younger women (ages 35-49) and older women (ages 50-70). By understanding these impacts, they hope to find better ways to manage blood pressure during and after menopause.

To be eligible for this study, women must be between 35 and 70 years old and have experienced either premature menopause (before age 40) or early menopause (before age 46). Participants should not be using tobacco products, have certain health conditions like diabetes or heart disease, or be pregnant or breastfeeding. Women who join the study can expect to undergo tests that will help researchers learn about how their body regulates blood pressure. This trial is currently recruiting participants, and it aims to provide valuable insights into the health of women experiencing menopause.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Aged 35-49 or 50-70 years of age who experienced premature (\<40) or early (≤45) menopause
• • Premenopausal 35-49 years of age
• • Typical-age menopause (i.e., after 45 years of age), who are between 50-70 years old
• • Menopause will be confirmed by subject report of amenorrhea for 12 months and serum FSH of \>30 mIU/mL
• Exclusion Criteria:
• • Current nicotine/tobacco use within the past six months
• • Are diabetic or asthmatic
• • Have diagnosed significant carotid stenosis
• • Have a history of significant autonomic dysfunction, heart disease, respiratory disease or a severe neurologic condition such as stroke or traumatic brain injury.
• • Have existing metabolic or endocrine abnormities
• • Take any heart/blood pressure medications that are determined to interfere with study outcomes
• • IF the participant is premenopausal AND currently taking OC or other exogenous steroids that are determined to interfere with study outcomes
• • Females who classify as having early or premature menopause AND are not willing to discontinue OC or MHT in order to complete the study
• • Are pregnant or breastfeeding