Mechanisms and Modulation of Pain Modulatory Capacity

Launched by UNIVERSITY OF FLORIDA · Jun 18, 2020

Keywords

ClinConnect Summary

This clinical trial is exploring how our bodies manage pain, particularly focusing on musculoskeletal pain, which affects muscles and bones. Researchers want to understand why some people experience pain differently and whether it's possible to train our bodies to handle pain better, similar to how athletes improve their performance through training. The study is currently looking for participants, including healthy individuals without any pain and those who have widespread muscle pain.

To be eligible, participants must be at least 18 years old. Healthy volunteers should not have any current pain, while those with widespread muscle pain must meet specific criteria for diagnosis. Participants can expect to engage in activities aimed at understanding and possibly enhancing their natural ability to manage pain. It's important to note that certain medical conditions, recent physical training, or specific pain treatments could disqualify someone from joining the study. This trial is a unique opportunity to contribute to new insights into pain management.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Asymptomatic people (ie no current pain conditions)
• • Participants with widespread muscle pain (WMP) aged 18 years of age and older
• • Participants with WMP must meet the ACR (2010) diagnostic criteria of multiple regions of muscle pain
• • The asymptomatic group will be free of current wrist/hand, elbow, or shoulder pain and chronic pain conditions (eg irritable bowel syndrome, FM)
• Exclusion Criteria:
• • 1. Participation in a conditioning program specific to the biceps in the past 6 months
• • 2. Any report of wrist/hand, elbow, or shoulder pain in the last 3 months
• • 3. Any chronic medical conditions that may affect pain perception (e.g., diabetes, high blood pressure), kidney dysfunction, muscle damage, or major psychiatric disorder
• • 4. Use of any intervention (including but not limited to medication, massage, and stretching) for symptoms induced by pain training for the duration of the study
• • 5. Positive result on pre-MRI metal screening or pregnancy test due to contraindication for the MRI environment.
• • 6. Any participant with ferromagnetic metal in the head, neck, or abdominal cavity