Prognostic Factors to Regain Consciousness

Launched by BDH-KLINIK HESSISCH OLDENDORF · Jun 23, 2020

Keywords

ClinConnect Summary

This clinical trial is studying patients with disorders of consciousness (DOC), which can occur after conditions like traumatic brain injury, stroke, or lack of oxygen to the brain. The main goal is to identify factors that can predict how well these patients will recover over time. Researchers will include 130 patients who are starting early rehabilitation. They will gather important information about each patient's condition and brain function right after they begin treatment and continue to check their progress weekly for up to a year.

To be eligible for this study, patients must be at least two weeks post-injury and have been admitted to the intensive care unit with a disorder of consciousness, such as being in a coma or having very limited awareness. Participants will undergo various tests, including brain scans and monitoring of brain activity, to help doctors understand their recovery potential better. It’s important to note that certain medical conditions or situations, like pregnancy or severe heart and lung issues, could prevent someone from participating. Overall, this study aims to provide valuable insights that could improve rehabilitation and outcomes for patients facing these challenging conditions.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • early neurological rehabilitation (phase B)
• • stroke, traumatic brain injury, hypoxic-ischemic encephalopathy
• • disorder of consciousness (coma, UWS, MCS)
• • at minimum two weeks after disease onset
• • admission to intensive care unit
• • written consent from the patient's legal representative
• • exclusion of pregnancy
• Exclusion Criteria:
• • insufficient cardiorespiratory stability
• • fractures or severe infratentorial brain injuries leading to impaired auditory evoked - potentials
• • previous brain damage
• • mental disorders (dementia, depression)
• • colonization with multi-resistant pathogens
• • MRI contraindications
• • claustrophobia
• • weight \> 120 kg