Bicarbonated Ringer's Solution Versus Lactated Ringer's Solution in Patients With Septic Shock

Launched by ZHONGNAN HOSPITAL · Jun 23, 2020

Keywords

ClinConnect Summary

Although the latest guidelines recommend crystalloids as the first choice for the patients' fluid resuscitation, it still remains controversial that which crystalloid solution is the best choice. It is reported that balanced crystalloid can result in better outcomes than saline for critically ill patients. However, there are few studies conducted between different crystalloid solutions.

Lactated ringer's solution is the longest-used crystalloid solution. Compared with lactated ringer's solution whose anion is lactate, the anion of bicarbonate ringer's solution is bicarbonate. And lactate n...

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Eligibility criteria

• Inclusion Criteria:
• • 1. At the age of 18 to 75;
• • 2. Being treated in the ICU;
• • 3. Diagnosed as septic shock according tho the definition of Sepsis 3.0 with fluid resuscitation requirement.
• Exclusion Criteria:
• • 1. Severe hepatic failure;
• • 2. Possible brain injury;
• • 3. With absolute contraindications for central vena catheterization;
• • 4. Ever participated in another clinical trial within 30 days prior enrollment;
• • 5. Have corrected metabolic acidosis through alkaline drug application within 24 hours prior to enrollment;
• • 6. Hypermagnesemia or hypothyroidism;
• • 7. Pregnant of breast-feeding women;
• • 8. Considered inevitable death;
• • 9. Other situations where investigators think enrollment is not appropriate.