Comparison of the Efficacy of Acupressure P6 Point, Dexamethasone and Ondansetron Versus Palonosetron Monotherapy for Preventing Postoperative Nausea and Vomiting in Laparoscopic Surgery

Launched by MOHD ZULFAKAR MAZLAN, MBBS · Jul 1, 2020

Keywords

ClinConnect Summary

This study is designed to compare the efficacy of palonosetron monotherapy versus combination of acupressure P6 point with dexamethasone and ondansetron in preventing PONV. It has been proven that palonosetron is more superior as single agent when compared with acupressure, dexamethasone and ondansetron separately. However, this might not be cost effective as palonosetron is more expensive than the other agents. In addition, the combination therapy has been reported better in preventing PONV when compared with monotherapy. The investigators need to investigate whether the combination of acu...

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Eligibility criteria

• Inclusion Criteria:
• • 1. ASA I or II female patients aged 18 - 65 years old in view female patients are at higher risk of postoperative nausea and vomiting.
• • 2. Patients undergoing laparoscopic surgery.
• • 3. High risk for PONV (APFEL score 3-4).
• Exclusion Criteria:
• • 1. Patients with known allergic to dexamethasone, ondansetron and wristband.
• • 2. Patients who take anti-emetic, emetogenic drugs and glucocorticoids within 24 hours before surgery.
• • 3. Patients with upper limb disability which affect the application of wristband.
• • 4. Obese patients with BMI \> 35 in view acupressure P6 wristband might be too tight to fit patient's wrist which might affect the correct placement of pressure point.
• • 5. Pre-existing vertigo