Characterizing Humoral Immune Response to Mosquito Bites

Launched by UNIVERSITY OF OXFORD · Jul 15, 2020

Keywords

ClinConnect Summary

This clinical trial is studying how the immune system reacts to mosquito bites, specifically looking at the saliva from different types of mosquitoes that can transmit diseases like malaria and dengue. Researchers are focusing on identifying certain markers in the blood that can indicate whether a person has been exposed to these mosquito bites. This information is important because it can help improve our understanding of how these diseases spread and test the effectiveness of interventions meant to control mosquito populations.

To participate in this study, you need to be healthy, between the ages of 18 and 60, and have lived in Mae Sot city for the past year. You should also be willing to allow yourself to be exposed to mosquitoes in a controlled setting. However, if you have certain health issues, like severe anemia or an allergy to mosquito bites, you won't be eligible. If you join the study, you can expect to learn more about how your body responds to mosquito bites, and your participation could contribute to important research in disease prevention.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Healthy male or female participant judged by a responsible physician with no abnormality identified on a medical evaluation;
• • Thai, Burmese or Karen ethnicity;
• • Aged ≥ 18 to \<60 years old;
• • Living in Mae Sot city for the last 12 months;
• • Willing to participate in the activity and able to give informed consent for participating in the study;
• • Able to tolerate direct mosquito exposure.
• Exclusion Criteria:
• • History of travel in a malaria endemic are (rural village) in the last 12 months, or plan to do so during the study;
• • Medication or condition deemed to interfere with the outcome measure by a responsible physician;
• • Moderate and severe anemia (haemoglobin concentration less than 110 g/L of blood);
• • Hypersensitivity or anaphylaxis to mosquito bites;
• • Pregnant women