Prevention of Vasospasm in SAH Through CSF Treatment

Launched by MEDICAL UNIVERSITY INNSBRUCK · Jul 24, 2020

Keywords

ClinConnect Summary

This clinical trial is investigating a new way to prevent complications in patients who have experienced a subarachnoid hemorrhage (SAH), which is bleeding in the area surrounding the brain. The focus is on using cerebrospinal fluid (CSF), the fluid that surrounds and protects the brain and spinal cord, to see if it can help reduce the risk of brain injury and improve outcomes for patients. The study aims to include 10 patients who have severe forms of SAH and will undergo a specific treatment involving draining excess CSF to relieve pressure in the brain.

To be eligible for this trial, participants need to be between 18 and 90 years old and have a specific type of aneurysm that requires treatment. They should also be diagnosed with a certain severity of SAH (grades 3 to 5 on a specific scale) and need to have their aneurysm repaired within 72 hours of the bleeding. Throughout the study, participants will receive careful monitoring and will have blood and CSF samples taken for further analysis. This research is crucial as it could lead to better understanding and treatment options for patients suffering from this serious condition.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age: \>18, \<90
• • SAH HH 3 - 5
• • Cerebral saccular Aneurysm
• • Digital subtraction angiography prior to aneurysm repair
• • Aneurysm repair within 72h
• • Modified Fisher Grade 3+4
• • Presence of aneurysm needing treatment (clipping or coiling)
• • Treatment within 24 hours of symptom onset
• • External ventricular drain (clinical need)
• Exclusion Criteria:
• • Non-aneurysmal SAH
• • SAH HH\<3
• • Extensive intraventricular haemorrhage (unable to obtain CSF without massive aspiration of clotted blood)
• • Contraindication for digital subtraction angiography
• • Aneurysm repair \>72h after rupture
• • Signs of radiographic vasospasm upon diagnosis
• • Presence of systemic or CSF infection
• • Contraindication for oral Nimodipin
• • Pregnancy