The Clinical Efficiency of Tb-ERA in Chinese RIF Patients

Launched by SHANGHAI JI AI GENETICS & IVF INSTITUTE · Aug 1, 2020

Keywords

ClinConnect Summary

In the field of assisted reproduction techonology, there are still 10% of patients with repeated implantation failure. In order to further explore the clinical utility of endometrial receptivity array in patients with repeated implantation failure, the patients divide into the experimental group or the control group. In the experimental group, those patients undergo endometrial receptivity array. In the control group, those patients do not receive any treatment before next cycle of transfer. In the experimental group, according to the results of endometrial receptivity array, the transplant...

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • 1. People with unexplained repeated implantation failure (3 or more times of transplantation, at least 4 or more high-quality embryos failed to conceive).
• • 2. Age: 20-40 years old.
• • 3. BMI: 19 - 24.
• • 4. The thickness of endometrium is more than or equal to 7 mm.
• Exclusion Criteria:
• • 1. Known causes of embryo implantation failure, such as infection, reproductive tract malformation, uterine cavity factors, immune factors, hydrosalpinx, etc.
• • 2. Decreased ovarian function (meet the following at least two criteria: ① 10u / L \< basal follicle stimulating hormone (FSH) \< 25U / L, and / or estradiol (E2) \> 292.8pmol/l, and / or FSH / LH \> 3; ② the number of antral follicles \< 5-7 on the second to third day of menstruation; and (or) antimullerian hormone (AMH) \< 0.5-1.1ng/ml.
• • 3. People with genetic history.
• • 4. Those who have done abortion and the histogenetic analysis are positive.