High-flow Nasal Cannula Oxygenation Decrease Hypoxia in Sedated Gastrointestinal Endoscopes in Obesity

Launched by RENJI HOSPITAL · Aug 2, 2020

Keywords

ClinConnect Summary

This clinical trial is looking at how a special type of oxygen delivery, called high-flow nasal cannula oxygenation, can help reduce low oxygen levels (hypoxia) during gastrointestinal endoscopies in obese patients who are sedated. Hypoxia can be a common problem during these procedures, especially in people with obesity. The goal is to see if using this high-flow oxygen method can make the procedure safer and more comfortable for patients.

To participate in this trial, you need to be between 18 and 70 years old and have a body mass index (BMI) of 28 or higher. You must be scheduled for a gastrointestinal endoscopy and have your consent or that of your family members. However, there are some health conditions that would exclude you from participating, such as severe heart problems, certain lung diseases, or recent major surgeries. If you join the study, you can expect to receive high-flow oxygen during your endoscopy, and the researchers will monitor how well it helps with your oxygen levels throughout the procedure.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • patients undergoing gastrointestinal endoscopes
• • age≥18 years old and ≤70 years old
• • patients or family members signed informed consent form
• • ASA classification I-II
• • BMI≥ 28kg/m²
• Exclusion Criteria:
• • Coagulation disorders or a tendency of nose bleeding;
• • An episode/exacerbation of congestive heart failure (CHF) that requires a change in medication, diet or hospitalization from any cause in the last 6 months;
• • Severe aortic stenosis or mitral stenosis;
• • Cardiac surgery involving thoracotomy (e.g., coronary artery bypass graft (CABG), valve replacement surgery) in the last 6 months;
• • Acute myocardial infarction in the last 6 months;
• • Acute arrhythmia (including any tachycardia - or bradycardia) with the fluid of hemodynamics instability;
• • Diagnosed chronic obstructive pulmonary disease or current other acute or chronic lung disease requiring supplemental chronic or intermittent oxygen therapy);
• • Increased intracranial pressure;
• • ASA classification Ⅲ-Ⅳ ;
• • Mouth, nose, or throat infection;
• • Liver and kidney disease
• • Fever, defined as core body temperature \> 37.5℃;
• • Pregnancy, breastfeeding or positive pregnancy test;
• • Emergency procedure;
• • Patients or family members refused to participate
• • Mental disorders and people without civil capacity