Beta Blocker Use In Traumatic Brain Injury Based On The High-Sensitive Troponin T Status

Launched by HAMAD MEDICAL CORPORATION · Aug 7, 2020

Keywords

ClinConnect Summary

The BBTBBT study is researching whether a medication called propranolol, which is a type of beta blocker, can help improve outcomes for patients who have suffered a traumatic brain injury (TBI). This study is particularly focused on patients with different levels of brain injury, from mild to severe. The researchers want to see if giving propranolol early, based on a specific blood test result (high-sensitive troponin T status), can reduce the risk of dying within 10 or 30 days after the injury.

To participate in this study, you need to be an adult between 18 and 65 years old who has experienced a blunt head injury that requires hospital admission. Unfortunately, certain individuals, such as those with severe injuries or specific health conditions, will not be eligible. If you qualify and choose to participate, you will be randomly assigned to receive either the propranolol or a placebo (a harmless substance with no active medication) without knowing which one you are getting. The trial aims to provide clearer evidence on the potential benefits of beta blockers in treating TBI, which could change how these injuries are managed in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • All adults (≥18 -65 years)
• • both genders
• • mild-to-severe blunt TBI (head AIS 1-5 and/ GCS 4-15) patients requiring hospital admission
• Exclusion Criteria:
• • Patients \<18 and\> 65 yrs old
• • penetrating trauma
• • non-survivable injuries (head AIS=6 \& GCS=3)
• • uncontrolled bleeding on arrival to ED
• • pregnant women
• • prisoners
• • patients with heart rate (HR) ≤70, systolic blood pressure (SBP) ≤100 mmHg (or MAP \<70 mmHg) not responding to initial management or required to be maintained on vasopressors on arrival .
• • Patients who will undergo hypothermia therapy,
• • any penetrating injury to head, thorax or abdomen,
• • history of bronchial asthma
• • patients posted for emergency surgery during the first 6 hrs.