Capturing MultiORgan Effects of COVID-19

Launched by UNIVERSITY OF OXFORD · Aug 11, 2020

Keywords

ClinConnect Summary

The C-MORE study is a research project aimed at understanding how COVID-19 can affect different organs in people who have survived the illness after being discharged from the hospital. Researchers want to find out how common these organ issues are and how they impact survivors' quality of life, ability to exercise, and mental health. The study is currently looking for participants aged 18 and older who have had a confirmed moderate to severe case of COVID-19 and have been hospitalized for at least 48 hours. There are also opportunities for healthy participants who have never had COVID-19 to join the study as a comparison group.

If you decide to participate, you will go through some assessments, including an MRI scan, to help researchers learn more about the effects of COVID-19 on your body. It's important to note that certain conditions, like pregnancy or having a pacemaker, may prevent someone from taking part in the study. The goal is to gather valuable information that could help improve care for future COVID-19 patients and understand the long-term effects of the virus.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Participant is willing and able to give informed consent for participation in the study.
• • Male or Female, aged 18 years or above.
• • Diagnosis of COVID-19 infection confirmed by detection of viral nucleic acid on reverse-transcription Polymerase Chain Reaction (RT-PCR).
• • Infection should be of moderate to severe intensity (i.e, patients with clinical signs of pneumonia such as respiratory rate \> 30 breaths/min; or severe respiratory distress; or SpO2 \< 90% (on room air) and admission for \>48 hours.
• • Controls: Participants with no serological evidence of previous infection, or active/previous symptoms suggestive of COVID-19, and who may or may not have comorbidities.
• Exclusion Criteria:
• • Contraindication to MRI e.g. pregnancy, pacemaker, ferromagnetic implant, shrapnel injury, severe claustrophobia, inability to lie flat.
• • Any other significant disease or disorder which, in the opinion of the investigator, might influence the participant's ability to participate in the study.
• • Any signs of active COVID-19 infection on day of visit.
• • Significantly impaired renal function (eGFR\<30 ml/min)