Vascular Biomarkers Predictive of the Progression from Gestational Hypertension to Preeclampsia in Pregnant Women

Launched by ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS · Aug 17, 2020

Keywords

ClinConnect Summary

This clinical trial is studying how certain changes in blood vessel function might help predict whether women with gestational hypertension—high blood pressure during pregnancy—will develop a more serious condition called preeclampsia. Preeclampsia can lead to complications for both the mother and the baby, so understanding who might be at risk is very important. The researchers aim to see if measuring specific blood vessel responses in pregnant women with stable hypertension can indicate the likelihood of developing preeclampsia later in their pregnancy.

To participate in this study, women aged 18 to 40 who are experiencing gestational hypertension or preeclampsia between the 20th and 26th week of pregnancy may be eligible. Participants will need to provide written consent and be part of a social security scheme. Those with certain health conditions that could affect blood vessel function or who are undergoing other treatments may not qualify. If you join the study, you can expect to undergo assessments to monitor your blood vessel health and help researchers learn more about managing these pregnancy-related conditions.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Patients with gestational hypertension and/or preeclampsia from the 20th amenorrhea week until the 26th ± 2 amenorrhea week.
• • Age between 18 and 40 years old.
• • Having given written consent
• • Patients affiliated to a social security scheme
• Exclusion Criteria:
• • Presence of pathologies interfering in a major way with vascular parameters: known multicomplicated diabetes treated before pregnancy, hypercholesterolemia known (or LDL\>130 mg/dl), connectivitis, proven cardiovascular disease (ischemic heart disease, stroke, arteriopathy of the lower limbs, heart failure), pre-existing known renal failure (MDRD \<60 ml/min) and/or pre-existing proteinuria ≥ 300 mg/24h).
• • Cardiac arrhythmia.
• • Hepatitis C, HIV infection (assay performed within 6 months prior to diagnosis of pre- eclampsia)
• • Recent history of venous (pulmonary embolism, phlebitis) or arterial (myocardial infarction, unstable angina, stroke, transient ischemic attack), thrombotic event ≤ 3 months.
• • Patient already engaged in a therapeutic protocol
• • Patients under legal protective measures
• • Patients receiving State Medical Assistance