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Search / Trial NCT04521790

Role of Endomyocardial Biopsy and Aetiology-based Treatment in Patients With Inflammatory Heart Disease in Arrhythmic and Non-arrhythmic Clinical Presentations: an Integrated Approach for the Optimal Diagnostic and Therapeutic Management

Launched by SCIENTIFIC INSTITUTE SAN RAFFAELE · Aug 17, 2020

Trial Information

Current as of June 26, 2025

Recruiting

Keywords

Myocarditis Ventricular Arrhythmias Arrhythmias Arrhythmogenic Inflammatory Cardiomyopathy Endomyocardial Biopsy Cardiac Magnetic Resonance Ablation Positron Emission Tomography Cardiac Imaging Electroanatomical Mapping Immunosuppressive Therapy Arrhythmic Risk Stratification Genetic Predisposition Environment Implantable Cardioverter Defibrillator Implantable Loop Recorder Multicenter

ClinConnect Summary

This clinical trial is focused on understanding and improving the diagnosis and treatment of myocarditis, a type of heart inflammation that can cause various symptoms like chest pain, heart failure, and irregular heartbeats (arrhythmias). Researchers want to find the best ways to identify the cause of myocarditis and how to effectively treat it, especially when it leads to arrhythmias. They are exploring different diagnostic methods, such as endomyocardial biopsy (a procedure to take heart tissue samples) and advanced imaging techniques like cardiac magnetic resonance (CMR) scans, to help diagnose and monitor the condition.

To participate in this trial, individuals must be at least 18 years old and have a suspected case of myocarditis, with their enrollment taking place at one of the participating centers. Participants can expect to undergo various tests and assessments as part of the study. The goal is to gather valuable information that could lead to better management of myocarditis and its related symptoms, ultimately improving care for patients who suffer from this condition.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Written informed consent.
  • Age ≥ 18 years.
  • Clinically suspected myocarditis.
  • Enrollment performed by one of the participating Centers.
  • Exclusion Criteria:
  • Absence of written informed consent.
  • Age \< 18 years (paediatric population).

About Scientific Institute San Raffaele

The Scientific Institute San Raffaele is a leading research and clinical care institution based in Milan, Italy, dedicated to advancing healthcare through innovative scientific research and high-quality patient care. With a strong emphasis on translational medicine, the institute integrates cutting-edge research with clinical applications, fostering collaboration among scientists, clinicians, and industry partners. San Raffaele is committed to enhancing the understanding of complex diseases and developing novel therapeutic strategies, thereby contributing to the improvement of global health outcomes. Its state-of-the-art facilities and multidisciplinary approach position the institute as a key player in the landscape of clinical trials and biomedical research.

Locations

Milan, Milano, Italy

Patients applied

0 patients applied

Trial Officials

Paolo Della Bella, MD

Study Chair

San Raffaele Scientific Institute, Milan, Italy

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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