Exercise-stimulated Muscle Glucose Uptake in Upper Body Obesity

Launched by MAYO CLINIC · Aug 27, 2020

Keywords

ClinConnect Summary

This clinical trial is exploring how exercise affects the way muscles use glucose (a type of sugar) in people with upper body obesity. The researchers want to understand how insulin, a hormone that helps control blood sugar levels, works with exercise to improve muscle function and glucose uptake. This is important because it could lead to better ways to manage obesity and improve health.

To participate in the study, you should be a premenopausal woman or an age-matched man who is either sedentary and normal weight or has upper body obesity. You also need to be stable in your weight for at least two months and willing to provide consent to join the study. Participants will likely engage in exercise and provide information that helps researchers learn more about how their bodies respond to physical activity. It's important to note that some people won't be eligible, like those under 18 or over 55, those taking specific medications, or individuals with certain health conditions. Overall, this trial aims to uncover valuable insights into the relationship between exercise and muscle health in people with upper body obesity.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• For the exercise studies of leg glucose uptake - "insulin sensitive" group:
• • Sedentary, normal weight, premenopausal women.
• • Sedentary, age-matched normal weight men.
• • Weight stable for two (2) months prior to study.
• • Willing to provide written, informed consent.
• * For the exercise studies of leg glucose uptake - "insulin resistant" group:
• For the exercise studies of leg glucose uptake - "insulin resistant" group:
• • Upper body obese (UBO) premenopausal women.
• • Age-matched upper body obese (UBO) men.
• • Weight stable for two (2) months prior to study.
• • Willing to provide written, informed consent.
• Exclusion Criteria:
• • Age \< 18 or \> 55 years (premenopausal women and age-matched men).
• • Use of glucose-lowering agents.
• • For female subjects: positive pregnancy test at the time of enrollment or study
• • History of prior upper abdominal surgery such as adjustable gastric banding, pyloroplasty and vagotomy.
• • Active systemic illness or malignancy.
• • Symptomatic macrovascular or microvascular disease.