How Early Mobilization Impacts on Diaphragm Thickness in Critically Ill Children

Launched by CHILDREN'S HOSPITAL OF FUDAN UNIVERSITY · Aug 27, 2020

Keywords

ClinConnect Summary

This clinical trial is looking at how early mobilization, which means getting children moving soon after they start needing help with breathing, affects the thickness of the diaphragm in critically ill children. The diaphragm is an important muscle that helps with breathing, and sometimes it can weaken when children are on a ventilator for a long time. The researchers want to see if getting kids moving early can help keep their diaphragm stronger compared to just routine care.

To be eligible for this study, children must be between 6 months and 12 years old, have been on a ventilator for less than 24 hours, and have a certain level of alertness when they arrive at the Pediatric Intensive Care Unit (PICU). It's important to note that children with specific medical issues, such as certain types of paralysis or serious injuries, won't be able to participate. If they join the study, participants can expect to be involved in activities designed to help them move while they are still receiving care, and the team will monitor their diaphragm thickness during this time. This could lead to better understanding and care for children who need breathing support.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • subjects \> 6 months and \< 12 years of age；
• • subjects been intubated and mechanically ventilated for \< 24 hours at the time of screening;
• • the Glasgow Coma Scale (GCS) on admission of Pediatric Intensive Care Unit (PICU) is greater than 3
• Exclusion Criteria:
• • cardiopulmonary arrest;
• • history of diaphragmatic paralysis or neuromuscular disease;
• • neuromuscular blockade;
• • expectation to be liberated from ventilator in \< 24 hours
• • history of mechanical ventilation in the last 6 months
• • presence of tracheostomy
• • high cervical spine injury
• • status convulsion
• • thoracic trauma when ultrasonic examination cannot be performed