Precision Diagnosis and Prospective Cohort Study for Myasthenia Gravis: Multicenter Analysis in China

Launched by HUASHAN HOSPITAL · Aug 27, 2020

Keywords

ClinConnect Summary

This clinical trial is studying myasthenia gravis (MG), a condition that causes muscle weakness and fatigue. The researchers aim to better understand how to diagnose and track the progress of MG in patients in China. They plan to recruit 300 individuals with MG and follow their health over time to learn more about the disease and how to manage it effectively.

To be eligible for this study, participants should have symptoms of muscle weakness that come and go, along with specific test results indicating MG. This includes certain changes seen in nerve tests or the presence of specific antibodies. Participants will need to be able to understand the study and agree to follow-up visits. It's important to note that people with other conditions that can mimic MG will not be included in the study. If you join, you can expect regular check-ups and support as researchers gather important information about your health and the condition.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• * fluctuating muscle weakness and fatigability, along with one of the below:
• • more than 10% amplitude decrement in low frequency repetitive nerve stimulation,less than 10% amplitude increment in high frequency repetitive nerve stimulation;
• • anti-AChR or MuSK antibody positivity;
• • positive to the neostigmine test;
• • understanding and assigning the informed consent form, and having a good compliance with the follow up.
• Exclusion Criteria:
• • excluding the possible diagnosis of Lambert-Eaton syndrome, congenital myasthenia syndrome,botulism injection, chronic progressive extraocular ophthalmoplegia, etc;
• • poor compliance to the follow up.