Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry

Launched by XIAOJUAN LI · Sep 1, 2020

Keywords

ClinConnect Summary

This clinical trial is studying new ways to use MRI (magnetic resonance imaging) to detect early problems in cartilage, which is the tissue that helps cushion joints. Currently, doctors mainly rely on X-rays and physical exams, which often only show advanced stages of conditions like osteoarthritis. The research aims to develop quicker and more reliable MRI techniques that can measure specific markers related to cartilage health. By improving these methods, the trial hopes to provide better tools for diagnosing and monitoring bone and joint diseases.

To participate in this study, you must be at least 18 years old, but there are different age criteria for specific groups. For example, one group includes individuals aged 18-50 who have recently suffered a complete tear of the ACL (an important ligament in the knee). However, some people may not be eligible if they have certain medical conditions, such as severe anxiety about being in MRI machines, or if they are pregnant. Participants can expect to undergo MRI scans and may also be involved in follow-up assessments to see how well the new imaging techniques work. Overall, this trial aims to help improve early detection and treatment options for cartilage-related issues.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Group 1
• • 1. Age \> 18
• • Group 2
• • 1. Age 18-50
• • Group 3
• • 1. Age 18-50
• • 2. Sustain an acute full ACL tear in one knee; the contralateral knee uninjured
• • 3. Undergo ACL reconstructions and standard rehabilitation
• • Group 4
• • 1. Age 18-50
• Exclusion Criteria:
• • Group 1
• • 1. Contraindication to MRI such as severe claustrophobia and implanted devices such as neurostimulators, pacemakers, aneurysm clips etc.
• • 2. Pregnancy.
• • Group 2
• • 1. Contraindication to MRI such as severe claustrophobia and implanted devices such as neurostimulators, pacemakers, aneurysm clips etc.
• • 2. Pregnancy.
• • 3. History of osteoarthritis and inflammatory arthritis
• • 4. Previous injury and/or surgery on either knee
• • Group 3
• • 1. Contraindication to MRI such as severe claustrophobia and implanted devices such as neurostimulators, pacemakers, aneurysm clips etc.
• • 2. Pregnancy.
• • 3. Inability to undergo standard pre- and post-injury/operative rehabilitation
• • Group 4
• • 1. Contraindication to MRI such as severe claustrophobia and implanted devices such as neurostimulators, pacemakers, aneurysm clips etc.
• • 2. Pregnancy.
• • 3. History of osteoarthritis and inflammatory arthritis
• • 4. Previous injury and/or surgery on either knee