PET Detection of CCR2 in Human Atherosclerosis

Launched by WASHINGTON UNIVERSITY SCHOOL OF MEDICINE · Aug 28, 2020

Keywords

ClinConnect Summary

This clinical trial, titled "PET Detection of CCR2 in Human Atherosclerosis," is studying a new imaging method to better understand a condition called carotid atherosclerosis, which is the buildup of fats and other substances in the arteries that can lead to serious health issues like strokes. Researchers are using a special radioactive substance called 64CUDOTA-ECL1i to see how it works in detecting this condition in patients.

To participate in the trial, you need to be between 50 and 89 years old and have been diagnosed with significant carotid artery atherosclerosis (more than 70% blockage) and scheduled for surgery. Some people who are younger (18-40 years old) and are healthy volunteers can also join. However, individuals with certain health issues, like severe diabetes, unstable health conditions, or those who cannot undergo specific imaging tests, will not be eligible. Participants can expect to undergo imaging tests and will be monitored closely throughout the study. It’s important to know that the trial is still looking for volunteers, and if you decide to participate, you will be helping researchers learn more about this condition and how to detect it better.

Gender

ALL

Eligibility criteria

• • Inclusion Criteria: Normal Volunteers: 18-40 years of age, non smoker, no history of diabetes, hypertension, or hyperlipidemia. Patients: 50-89 years of age, adequate nutritional status, with or without smoking history, diabetes, hypertension, and hyperlipidema. Both asymptomatic and symptomatic patients with known carotid artery atherosclrosis \>70% and scheduled to undergo surgery. Advanced peripheral artery disease.
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• • Exclusion Criteria:Inability to receive and sign informed consent. Currently enrolled in another study. Patients who have type 1 diabetes or are in septic shock, receiving steroid therapy, recent history of heavy alcohol consumption, (male \>2 drinks per day, and female \> 1 drink per day. following extreme diets like Atkins or South Beach diet or with Stage 4 chronic renal failure. Patients with unstable clinical condition that in the opinion of the PI precludes participation in the study. Inability to tolerate 60 minutes in a supine position with arms down at sides. Contraindications to MR imaging, (pacemaker, brain aneurysm clips, shrapnel, etc. Positive pregnancy test or lactating. Have another conditions such as cancer or autoimmune/inflammatory diseases, e.g. rheumatoid arthritis or multiple sclerosis that are known to have increased expression of CCR2.
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