DASH INtervention to INvestigate the Gut

Launched by H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE · Aug 29, 2020

Keywords

ClinConnect Summary

This clinical trial is investigating how different diets affect gut health in a diverse group of adults. Researchers will recruit 112 generally healthy participants from Birmingham, AL, who are between 19 and 65 years old, to follow either the DASH diet or a standard American diet for 28 days. The DASH diet focuses on fruits, vegetables, whole grains, and lean proteins, while the standard diet is more typical of what many people in the U.S. eat. Participants will receive all their meals from the study and will need to visit the UAB Bionutrition Unit daily to pick them up. During the trial, researchers will collect samples from participants to study the bacteria in their guts and look for changes that might be linked to a healthier gut and a lower risk of chronic diseases like cancer.

To be eligible for the study, participants must be black or white, non-Hispanic, and without any significant gastrointestinal issues or major medical conditions. They should not have taken antibiotics or probiotics in the past three months, and they should not be smokers or heavy drinkers. By comparing the effects of these two diets, the researchers hope to find evidence that the DASH diet can help improve gut health across different racial groups, potentially reducing the risk of conditions like colorectal cancer in the long run.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • black or white race
• • non-Hispanic ethnicity
• • age 19-65 years
• • able to travel to the UAB Bionutrition Unit daily to retrieve meals
• Exclusion Criteria:
• • gastrointestinal (GI) conditions i.e., irritable bowel, diverticulitis, peptic ulcers, Crohn's, GI cancers, and adenatomous polyps
• • antibiotic or probiotic use in the previous 90 days
• • smoking/tobacco use
• • heavy alcohol consumption
• • major medical conditions (e.g., renal disease, diabetes, cancer