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Search / Trial NCT04543253

Recovery From Cushing Syndrome and Mild Autonomous Cortisol Secretion (MACS)

Launched by MAYO CLINIC · Sep 8, 2020

Trial Information

Current as of July 24, 2025

Recruiting

Keywords

Hypercortisolism Cushing Syndrome Cushing Disease Pituitary

ClinConnect Summary

This clinical trial is studying how people recover from Cushing syndrome (CS) after surgery, particularly focusing on the effects of glucocorticoid withdrawal syndrome (GWS). Cushing syndrome is a condition caused by too much cortisol in the body, often leading to various health issues. After surgery to correct this problem, patients may experience symptoms from suddenly lowering their cortisol levels, known as GWS. The study aims to find out what factors may predict how long and how severe these withdrawal symptoms will be and to see if a specific intervention, called MUSE, can help reduce the severity of these symptoms compared to standard care.

To participate in this trial, individuals must be 18 years or older and have a new diagnosis of Cushing syndrome, including its various forms. They should also be planning for curative surgery and able to provide informed consent. Participants can expect to be closely monitored before and after their surgery to track their recovery and any symptoms they experience. This trial is currently recruiting participants, and it's important for those interested to understand that their involvement could contribute valuable information about managing recovery from this complex condition.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • 1. age 18 and above,
  • 2. new diagnosis of CS of any of the three subtypes (pituitary, adrenal or ectopic CS), and MACS,
  • 3. planning for a curative surgery
  • 4. ability to provide informed consent.
  • Exclusion Criteria:
  • 1. systemic supraphysiological GC for any reason within 1 month of enrollment, for more than 2 weeks,
  • 2. inability to provide informed consent

About Mayo Clinic

Mayo Clinic is a renowned nonprofit medical practice and research institution dedicated to providing comprehensive healthcare and advancing medical knowledge through innovative research and education. With a commitment to patient-centered care, Mayo Clinic conducts numerous clinical trials aimed at exploring new therapies and improving treatment outcomes across various disciplines. Leveraging a multidisciplinary approach, the institution collaborates with leading experts and cutting-edge technology to ensure rigorous scientific standards and ethical practices in all its research endeavors. Through its trials, Mayo Clinic seeks to translate breakthroughs in science into tangible benefits for patients, fostering advancements in medicine that enhance health and quality of life.

Locations

Rochester, Minnesota, United States

Patients applied

0 patients applied

Trial Officials

Irina Bancos, MD

Principal Investigator

Mayo Clinic

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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