Better Mechanistic Understanding of and Risk Stratification for Ventricular Tachyarrhythmias Through ECGI

Launched by MAASTRICHT UNIVERSITY MEDICAL CENTER · Sep 8, 2020

Keywords

ClinConnect Summary

ECGI combines electrical body-surface mapping with 256 electrodes placed on the thorax with a CT-scan obtaining the anatomy of the heart and torso, hereby able to reconstruct local electrograms, activation and recovery times. In recent research, ECGI provided numerous extra insights into normal cardiac electrophysiology, but also electrophysiological disorders and disease. The results strongly suggest that ECGI can play a pivotal role in further characterizing arrhythmia mechanisms, therefore could do so for VTAs, leading to diagnosis and treatment improvement. Moreover, ECGI seems to have ...

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Eligibility criteria

• Inclusion Criteria:
• In order to be eligible to participate in this study, a subject must be ≥ 18 years old, have either a history of VTAs or be at risk of VTAs and have one of the following diagnoses:
• • Ischemic cardiomyopathy
• • Non-ischemic cardiomyopathy
• • Non-structural heart disease
• • Congenital heart disease (with a limitation to CCTGA and situs inversus)
• • Or: a subject must be ≥ 18 years old and have a structurally normal heart with a clinical indication for a cardiac CT.
• Exclusion Criteria:
• A potential subject who meets any of the following criteria will be excluded from participation in this study:
• • A known strong reaction against electrode attachment or contrast agent.
• • Any serious medical condition, which in the opinion of the investigator, may adversely affect the safety and/or effectiveness of the participant or the study.
• • Pregnancy, nursing or planning to be pregnant.
• • The subject has an estimated glomerular filtration rate (eGFR) of \<30mL/min/1.73m2, using the MDRD calculation 14.
• • Being unable to give informed consent.