Primary TBE Vaccination for the Elderly

Launched by REGION ÖREBRO COUNTY · Oct 1, 2020

Keywords

ClinConnect Summary

This clinical trial is studying how an extra dose of the Tick-borne Encephalitis (TBE) vaccine might help older adults build better immunity against the virus. TBE is a serious illness that can be prevented with a vaccine, but older people often don’t respond as well to the vaccine as younger individuals. Researchers want to see if giving an additional dose of the vaccine to people over 50 years old can improve their immune response, making it more similar to that of younger vaccinated individuals.

To take part in this study, participants need to be at least 50 years old, or between 18 and 40 years old, and in good health. They must not have been vaccinated against TBE before or have any serious health conditions that could interfere with the study. Those who join will receive the vaccine and help researchers understand if this new approach makes a difference in protecting against TBE. It’s important to note that the study is not yet recruiting participants, so there will be more information available soon for those interested in participating.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults ≥ 50 years or between 18-40 years
• • Man or woman
• • God health
• • Written informed consent
• Exclusion Criteria:
• • Previous vaccination against TBE
• • Previous TBE infection
• • Allergy or hypersensitivity to any substance in the vaccine
• • Previously known or suspected infection with Japanese encephalitis, Dengue virus, West Nile fever or Yellow fever
• • Information on previous vaccination against Yellow fever or Japanese encephalitis
• • Acute illness, eg fever with malaise
• • Immunosuppression, due to medication or disease
• • Previous treatment with Rituximab or equivalent
• • Autoimmune disease, including diabetes (diet or tablet-treated diabetes with good metabolic control is accepted, HbA1c \< 6 %)
• • Obesity, BMI \> 40
• • Moderate to severe renal failure including hemodialysis, estimated GFR \< 30.
• • Blood transfusion or immunoglobulins \<3 months ago
• • Pregnancy
• • Any other illness where the investigator consider the subject unsuitable for the study
• • The study subject does not want to participate